BIOC 3560 Study Guide - Midterm Guide: Sickle-Cell Disease, Intimate Ion Pair, Cooperative Binding

• School: University of Guelph
• Department: Biochemistry
• Course: BIOC 3560
• Professor: John Dawson

Document Summary

Complimentary shapes of substrates (or ligands) and their binding sites on an enzyme. Conformational change in hexokinase induced by binding of d-glucose (red) Function is influenced by interactions w. other molecules. Prosthetic group: a compound/cofactor permanently associated w. a protein and required for its function. Or interactions can be transient and short lived. Ligand = molecule that is bound reversibly by a protein. Binding site = position on a protein that interacts with a ligand. Induced fit = structural adaptation between protein and ligand. Enzymes a special case of protein-ligand interaction. Substrate (~ligand) = a molecule changed by an enzyme. Catalytic site or active site (~ligand-binding site) = binds substrate and facilitates its chemical transformation. ** conformational change can make binding site more complementary. **transporters help get molecules across the membrane becareful w. word transporter (cid:494)structural proteins(cid:495) control their assembly or disassembly. ** remember not having enzyme activity does not mean it has no function.