BIOC 3560 Study Guide - Comprehensive Midterm Guide: Hbb, Protein Kinase A, Conjugated System
5 Oct 2016
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Document Summary
Properties that interest is: size (molecular weight; 5,000-500,000 daltons. H+ = 1d, c = 12 d: shape (structure, fold, charge (+ve/-ve patches, hydrophobic/hydrophilic properties. Why do we care about protein structure: understand how a protein works by looking at it at the atomic level. Structure/function relationship: can explain a lot of biochemical effects. How life processes work (health) and why some don"t (disease) Reversible modulation of protein function: proteins are dynamic molecules, their function is influences by interactions with other molecules, interactions can be stable. Prosthetic group: a compound/cofactor that is permanently associated with a protein and is required for its function: or they can be transient and short-lived (milliseconds-hours) Ligand: a molecule that is bound reversibly by a protein. Binding site: position on a protein that interacts with a ligand. Must be complementary in: size, shape, charge (one -, one +), and polarity (one polar, one non-polar (this also means hydrophobicity) Induced fit: structural adaptation between protein and ligand.
