BIOC 2580 Study Guide - Final Guide: Frameshift Mutation, Exon, Stop Codon
16 Dec 2015
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Document Summary
Prevent expression of potentially harmful mrnas from being exported into cytoplasm. Rapid mrna decay method developed so (labile mrnas) growth factors, cytokines and oncoproteins are not overexpressed. Auuua motif in 3" utr of these kinds of mrnas to allow them to be very unstable unless they are needed. Usually multiple repeating motifs in the 3" utr of mrnas that decay through this method. Are: au rich elements (cis-acting factors) destabilize mrnas by promoting amd. Based on the number of repeats in the auuua motif, are-containing mrnas are divided into classes. Aubps bind to the are-binding proteins and either stabilize or destabilize based on the aubp. Destabilizing aubps can interact with decapping, deadenylation, or exosome proteins to promote decay. Stabilizing aubps (usually trans-acting rbps) are thought to outcompete binding of destabilizing proteins to are or can stabilize the circularization of mrna by interacting with polya binding protein.
