ANSC 3080 Study Guide - Final Guide: Pyridoxal Phosphate, Glutamate Dehydrogenase, Urea Cycle
Document Summary
Amine and carboxylic acid functional groups (always, at least one) Ketone and carboxylic acid functional groups (always, at least one) Glutamate = source of free nh3, participates in all transamination reactions. Aspartate = carries n into urea cycle (not essential bc made in body) Alanine = interorgan n transporter, important for exchange btw tissues (goes to liver, and made into urea) Glutamine = interorgan n transporter, source of free nh3 (goes to liver and kidney) **found in highest [] in body. Constant turnover, always being synthesized and always being degraded. 80% reutilization of aas , 20% catabolism of aas. If taken in more than necessary, degrade and excreted. **can"t reuse n so we get rid of it, reuse the carbon skeleton. Fate of nh3 (nh4+) from aa catabolism will depend on metabolic state. Fed = to liver urea (via glutamine and alanine) Active tca cycle, generates co2 hco3- (bicarbonate) A lot of co2 produced and made into bicarbonate.