ONCOL320 Study Guide - Midterm Guide: Type Iv Collagen, Telomerase Reverse Transcriptase, Paneth Cell
5 Nov 2016
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Terms & molecules for oncology 320 midterm 2 htert - human telomerase reverse transcriptase; only expressed in select cell types (stem cells, germline cells, etc. ); cells that express htert are able to bypass senescence and crisis htr - human telomerase rna, acts as template for extension of telomeric sequences; expressed constitutively. Alt - alternative lengthening of telomeres: mechanism by which telomeres are lengthened using the telomere template of another chromosome + dna repair mechanisms. Paneth cells - immune cells in the colonic crypt that protect intestinal stem cells. Mdr-1: multi-drug resistance 1 gene --> expresses a d-glycoprotein that actively excrete mutagen (and chemotherapy agents); expressed by most stem cells and tumour cells (tics and bulk tumour cells) Bcl-2 - normally pro-survival, blocks apoptosis when overexpressed. Myc - induces proliferation ras - induces anchorage independence src - induces anchorage and serum independence. Sv40 large t antigen - inactivates p53 and prb (forces cell through cell cycle checkpoint --> proliferation)
