NURS 216 Study Guide - Quiz Guide: Drug Metabolism, Glutathione, Tylenol (Brand)
15 Sep 2019
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<4/10: non-opioid medications such as nsaids and tylenol. 4-6/10: po opioid such as codeine and morphine. Robax if inflammation is also present with low to moderate pain (ibuprofen with muscle relaxant) Overdose: depletes stores of glutathione, resulting in the buildup of toxic intermediate. Po excellent bioavailability peak plasma concentration 30-60 minutes metabolite. Renal excretion half life 2-3 hours hepatic metabolism cyp 3a4 & 1a2 toxic metabolite: n-acetyl benzo from phase ii metabolism (glutathione) Take caution with severe asthmatic patients due to opioid stimulated histamine release. Cns depression (hold opioids if respiratory rate is less than 12/minute) High efficacy (mu- receptor agonist) fentanyl hydromorphone (dilaudid) oxymorphone (numorphan) Low efficacy codeine tylenol 1-4 (acetaminophen + codeine + caffeine) C = slowest transmission (gate control theory) Activity signals a massive efflux of dopamine into the synaptic cleft. Useful if pain is associated with inflammation caused by cellular injury (not allergy) Lipids: synthesized from essential fatty acids (within a cell) using cyclooxygenase (cox)
