NURS 3550H Study Guide - Comprehensive Final Exam Guide - Hypertension, Epinephrine, Vasoconstriction

• School: Trent University
• Department: Nursing
• Course: NURS 3550H
• Professor: Jane Mackie

Document Summary

Receptors: (mu), (kappa), (cid:303), , (cid:304) http://www. the-scientist. com/feb2014/feature1_pg36full. jpg. Several routes: oral, intramuscular, intravenous, subcutaneous, epidural, and intrathecal. Not very lipid-soluble: does not cross blood-brain barrier easily, fraction of dose reaches site of analgesic action (in the brain, also works locally. Cyp 2d6, cyp 3a4 metabolize several opioids. Genetic variability in opioid response especially with 2d6. Cough centre: medulla, suppress activity of cough reflex. Gi: dec tone and sphincters, direct in gi and indirect in cns, biliary colic. Prolonged use: neurotoxicity, decreased cortisol levels increased prolactin levels, decreased lh, fsh, t, e immunosuppression. Therapeutic indications: treatment of moderate to severe pain. Dec substance p (neuro transmission involved in pain transmission) Atch opioid with degree of patient"s pain https://lh6. googleusercontent. com/rxyyspiuhwevoo0ocflrxkjk6cmfry5qihzz- j_b_rlfshuhz78sujdiyxeryhouwurxdiw7pasvumwnu4zkejmwigv- rutsoco6bas3bjq5wlrcfe6r4skknq. Loperamide (otc) this is what is in imodium. Does not cross bbb (derivatives that do not cross the bbb at all: diarrhea, cough suppressant. Opioid receptors in the medulla suppress cough reflex.