PSYC 280 Study Guide - Final Guide: 5-Ht Receptor, Partial Agonist, Loxapine

• School: Simon Fraser University
• Department: Psychology
• Course: PSYC 280
• Professor: Neil Watson

Document Summary

Blockade of serotonin receptors; reduce negative-symptoms (social withdrawal, blunted emotional responses) Inhibit the breakdown of monoamine nts, therefore allowing monoamine nts to accumulate at the synapses = improved mood. Increase the synaptic content of the monoamines (ne and serotonin) by blocking reuptake into the presynaptic axon terminal. Reduce anxiety, promote sleep, prevent seizures, analgesic, anticonvulsant effects. Bind to specific sites on gabaa receptors to enhance gaba activity (inhibitory = reduction in excitability of neurons) A seraotonergic agonist & a partial agonist of dopamine d2 receptors. Psilocybin ("magic mushrooms") mimics endogenous opiates, therefore binding to opiate receptors (endogenous opiates shut down the release of dopamine-inhibiting nts) so dopamine is released and floods the synapse. Body"s endogenous cannabinoid = anandimide (activates cannabinoid receptors to turn off the dopamine-inhibiting nts). Thc mimics anandimide; thus dopamine is allowed to rush into synapse (removes unnecessary short-term memory; slows movement = relaxed, calm; stimulates appetite; reduced sensitivity to pain; lowered blood pressure; combats nausea)