MBB 222 Study Guide - Final Guide: Tetrahedral Carbonyl Addition Compound, Alkoxide, Nucleophile

• School: Simon Fraser University
• Department: Molec Biol & Biochem
• Course: MBB 222
• Professor: Edgar Young

Document Summary

Mbb222 exam vocab definitions: acid-base and covalent catalysis. Uten-01 must proton transfer (special case of a group transfer) Charged intermediates in a reaction can be stabilized by the transfer of protons to or from the substrate or intermediates to form a species that can break down more readily to the products. Proton transfers can involve either water or other weak proton donors/acceptors. Uten-01 first general acid-base catalysis (= proton transfer catalysis) Refers to proton transfers that are mediated by weak acids and bases other than water (specific acid-base catalysis refers to only using water, oh and. This catalysis is crucial in the active state of an enzyme where water may not be readily available. Several different amino acid side chains can take the role of proton donors and acceptors as they are precisely positioned in an enzyme active site to allow for proton transfers. Glu, asp, lys, arg, cys, his, ser, tyr.