PAT 20A/B Study Guide - Midterm Guide: Migraine, Neuromuscular-Blocking Drug, Borderline Personality Disorder
23 Feb 2016
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1 divalproex sodium (mood stabilizers/anticonvulsants: 1462, 1528. Probably facilitates the effects of the inhibitory neurotransmitter. Dizziness, headache, abdominal pain, anorexia, vomiting, nausea, diarrhea. Give drug with food or milk to reduce adverse. Probably alters chemical transmitters in the cns, possibly by interfering with ionic pump mechanisms in brain cells, and may compete with or replace sodium ions. To prevent or control mania in bipolar disorder. Fatigue, lethargy, tremors, drowsiness, headache, blackouts, reversible ecg changes. Important ones (bolded): coma, arrhythmias, bradycardia ** renal toxicity with long term use. Calcium channel blockers may decrease lithium levels and increase risk of neurotoxicity. May increase glucose and creatinine and tsh levels. May decrease sodium, t3, t4 and protein- bound iodine levels. May increase i uptake and wbc and neutrophil counts. Pts with seizure disorder, infection, renal or cv disease. Thiazide diuretics may increase reabsorption of lithium by kidneys, with possible toxic effects.
