PAT 20A/B Study Guide - Final Guide: Peptic Ulcer, Noxious Stimulus, Spasm

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Stimulation of nociceptors: nociceptors respond to several forms of stimulation: Mechanical, thermal, and chemical: process--- called nociception. The change in the senses induced by a noxious stimuli: mechanical stimuli. Arise from intense pressure applied to skin. From the violent contraction or extreme stretch of a muscle. Both extremes of heat and cold can stimulate nociceptors: chemical stimuli. Several chemical mediators are released from injured and inflamed tissues--- hydrogen, potassium ions, prostaglandins, leukotrienes, histamine, bradykinin, serotonin. These chemical mediators produce their effects by directly stimulating nociceptors or sensitizing them to the effects of nociceptive stimuli. Sharp, pricking, burning sensation sharp pain with a burning quality. Such as the periosteum, muscles, tendons, joints, and blood vessels. The pain is more diffuse than cutaneous pain: cutaneous tenderness, hyperalgesia (increased response to painful. Diffuse & radiating stimuli: hyperesthesia ( increased sensitivity to pain, allodynia ( pain from a non-noxious stimuli) Deep somatic pain can be produced by: