MICR 221 Study Guide - Final Guide: Immediate Early Gene, Innate Immune System, Viremia
12 Mar 2017
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Document Summary
Core enters cell, there is some transcription in the. Brings in an rna polymerase and a dna polymerase (they replicate in cytoplasm, can"t have access to nucleus polymerases) Some proteins that it secretes from the cell in the early phase, made immediately. B18r: interferon decoy, to deal with innate immune response (ifn) Early phase protein (gene regulatory) disassembles core further, also involved with viral dna replication. Intermediate phase proteins (gene expression/replication) = transcription factors (regulate expression/timing of late gene products) Late phase proteins: structural proteins and polymerase proteins that must be packaged. Immature virion becomes mature virion after er --> can lyse cells to go out, or golgi to become. Wrapped virion (acquire 2 more membranes through golgi --> actin. This triggers polymerization of actin so that it"s pushed. Driving into the adjacent cell results in loss of the last extra membrane to actually resemble a. Cell fuses envelope at envelope to release tegument and capsid into cytoplasm.
