BIOL 330 Study Guide - Final Guide: Oregon Route 8, Western Corn Rootworm, Myogenesis
23 Feb 2017
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Randall weems: tells proteins they need to be degraded. Stands for rna interference- small rna molecules that affect gene expression. Pre-transcriptional inhibition through epigenetic changes resulting in heterochromatin: heterochromatin cannot be transcribed by rna polymerase. Post-transcriptional repression and inhibition through silencing and splicing respectively. Snorna- small nucleolar rna: found in nucleolus, regulatory rna responsible for post- transcriptional maturation of ribosomal rnas (rrnas) Involved in splicing of pre-mrna molecules: found in nucleus, build structure of the spliceosome, maintain telomeres sirna. Exogenous- from outside cell: enters body from infection by single-stranded rna (ssrna) viruses with a double-stranded rna (dsrna) intermediate or dsrna viruses (ie. rotavirus), or by simple transfection. Gene expression regulation: transcriptional (chromatin silencing), post-transcriptional (mrna degradation), translational (blocking ribosomes) Short double-stranded rna molecules (21-23 nucleotides) with hairpin loop. Gene expression regulation: post-transcriptional (mrna degradation), translational (blocking ribosomes) Most processing occurs in nucleus, with some in cytoplasm. Both are cleaved by dicers: mirna hairpin is cleaved.
