BCHM 310 Study Guide - Midterm Guide: Lone Pair, Covalent Bond, Protein Folding

• School: Queen's University
• Department: Biochemistry
• Course: BCHM 310
• Professor: Robert Campbell

Document Summary

Ionizable: acts as a weak acid or base. Shorter h bonds are stronger, linear arrangement of 2en and 1 h atom. Directional, 20x weaker than covalent but 5x stronger than van der b/n 2 atoms. Ice: 4 h bonds (2 h and 2 lone pair e-) Liquid: can tumble w 3. 4 h-bonds, flickering clusters- lifetime of h bond=1- Ex nacl: forms electrostatic interactions w h2o, na+ will point twrds o, cl w h (6 h2o/ion) Electro interactions b/n water and ions compensate for water-water h bonds and disruption of nacl crystals. H>0, entropy of nacl increases s>>0, g<0 (fav) H2o forms h bonds to polar solutes so h is close to 0 and s>>0 so g<0 (fav) No h bonds b/n h2o + solute, only weak van der waals. Dissolving solute: h2o is more ordered and constrained so s<0, h>> 0 (loss of h bonds) and g>0 (unfav) Dissolved solute: some h2o released into bulk solvent.