LIFESCI 3N03 Midterm: 3N03 M4 Iron
18 Feb 2019
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Document Summary
A cereal based diet is especially deficient in iron pregnant women need 27mg/day. Iron de ciency < iron homeostasis < iron overload. Iron de ciency anemia (ida) - other factors renal disease (decreased epo synthesis) anemia of inflammation (ai) hereditary iron-refractory ida (irida) loss of function mutation in tmprss6 gene encoding matriptase-2 = a negative regulator of hepcidin. Congenital ida due to mutation of dmt1 cause problems in absorption of iron - won"t be able to bring it into cytosol poor diet/low stores + pregnancy. Development of ida - stages: depletion of iron stores, decrease amount of iron in circulation, decreased rbc production. Iron overload - acute impairs the oxygen carrying capacity of the blood weakness, impaired effort tolerance and heart failure in children: impaired psychomotor development, attention and other cognitive problems in pregnancy: prematurity, low birth weight, increase perinatal mortality. Ul = 45 mg/day primary cause: accidental over-consumption of iron supplements or iron-containing vitamins exceeds capacity of transferrin transport.
