HTHSCI 3I03 Study Guide - Midterm Guide: B-Cell Receptor, Ralph M. Steinman, Mucociliary Clearance
25 Aug 2016
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Document Summary
We are continuously exposed to environmental agents, both infectious and non-infectious in nature. Multiple host defense mechanisms protect us against potentially harmful viruses and bacteria. 3 important components: physical barriers: epithelium, mucous, mucociliary clearance, innate immunity: lung resident defence, peripheral defense mechanisms, adaptive immunity: t cell (cellular), b cell (humoral, mediated by macromolecules) It"s a continuum, each have different characteristics but work hand in hand. All bone marrow derived, bone marrow is a primary immune organ. Pattern recognition receptors (prr) recognize common molecular patterns of pathogens referred to as pathogen associated molecular patters (pamps) Scavenger receptors, toll like receptors (tlr), nod like receptors, etc. For b cells, the cell surface receptors for pathogens are immunoglobulins. For t cells, the cell surface receptors are known as t-cell receptors. On activation by infection, b cells divide and differentiate into plasma cells, whereas. T cells differentiate into various types of effector t cell (variety of functions)
