PHGY 210 Study Guide - Midterm Guide: Growth Hormone–Releasing Hormone, Thyroid Hormone Receptor, Thyrotropin-Releasing Hormone
7 Sep 2017
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Cell immediately adjacent; secretion never really enters the systemic circulation. Cell onto a target cell; signaling substance. Ex: endothelial cell signaling another endothelial cell beside it: autocrine signaling. Cell talking to itself; released substance, ex: growth factor. Ex: releases cytokines (immune system hormones) and has receptors on its surface for those cytokines. ** all these steps are potential sites of regulation! Detection of the hormone leads to a biochemical change in the cell (changes how it functions). Hypothalamic-pituitary signaling via blood vessels of the pituitary stalk. Hypothalamic-hypophyseal portal system delivers hormones directly from the hypothalamus to the anterior pituitary. Hypothalamic neurohormones either activate or inhibit activity of one of the six types of hormone producing cells in the anterior pituitary. Called either releasing hormones (releasing factors) or inhibiting hormones (inhibiting factors). Prepropeptide sequence is fundamental to function of hormones as it directs them into the secretory pathway of cells.
