BIOL 2020 Study Guide - Final Guide: Fibril, Nuclear Matrix, Proline
10 Dec 2015
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Document Summary
The nucleus is enclosed by a nuclear envelope: forms a boundry between the nucleus and the cytoplasm. The inner surface of the nuclear envelope is bound by integral membrane proteins to a ilamentous network called the nuclear lamina: nuclear lamina provides support, serves as site of attachment for chromatin ibers at the nuclear periphery. Filaments of nuclear lamina ~10 nm in diameter and composed of polypeptides called lamins. Lamins are part of the same group of polypeptides that form intermediate ilaments: integrity of lamina is regulated by phosphorylation and dephosphorylation. Disassembly of nuclear lamina prior to mitosis is induced by phosphorylation of the lamins by a protein kinase o. The structure of the nuclear pore complex and its role in nucleocytoplasmic exchange: nuclear pores act as gateways for macromolecules. Replication and transcription of dna requires the recruitment of proteins that are synthesized in the cytoplasm and transported across the nuclear envelope.
