BIOL 266 Study Guide - Midterm Guide: Glycosylphosphatidylinositol, Membrane Transport Protein, Calcium Atpase

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30% of all proteins in a cell are associated with a membrane. 60% of targets of drugs are membrane proteins. 50% of membrane weight is protein (much larger than lipids so there are 50-100 lipids per protein) ***membranes are made of: lipids (structural elements) and proteins (carry out specific functions) Amphipathic (hydrophobic inside bilayer and hydrophillic form domains outside bilayer). They form van der waals interactions with the lipids: monotopic. Odd number: in-out (one end inside one end outside) Usually the hydrophobic portion is made of non-polar, non charged amino acids and hydrophillic portion of charged, polar amino acids: even number: in-in or out-out (both ends on the same side) Protein is linked to a lipid which is embedded in the membrane. Two types: gpi-anchored: protein has covalent bond with glycosylated phosphatidylinositol (glycosyl phosphatidylinositol) mainly external, fatty acid anchored: protein is linked to fatty acid, usually myristic acid or palmytic acid.

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