NEUR 3202 Study Guide - Final Guide: Dopamine Receptor D2, Nmda Receptor, Reduced Properties
Document Summary
Colorless volatile alkaloid found in tobacco leaves and is poorly absorbed by the digestive tract. Tar:a term used to describe the toxic ingredients found in cigarettes and is an. Important contributor to the taste and smell of cigarette smoke, and contributes to the reinforcing effect of smoke. 70-80% of nicotine in the body is transformed into the principle metabolite called cotinine. An enzyme called cytochrome p450 2a6 breaks it down. Breaks down nicotine into the principle metabolite called cotinine. Begins with stimulation of nicotinic cholinergic functions but then turns to a nicotine receptor block. High doses allows a persistent activation of nicotine receptor causing continuous depolarization of the posystnaptic cell where the cell cannot fire until nicotine is removed. Mecamylamine: nachr antagonist that compeltly blocks the effects of tobacco smoke on dopaminergic firing demonstrating that these effects are mediated by nicotine cholinergic receptors.
