BIOL 2P03- Midterm Exam Guide - Comprehensive Notes for the exam ( 82 pages long!)

• School: Brock University
• Department: Biological Sciences
• Course: BIOL 2P03
• Professor: Mark K Lukewich

Document Summary

Week 5 screencast vesicular traffic, secretion and endocytosis. Signal based targeting: used by protein that are destined fro the er, mitochindria, nucleus, chloroplasts and peroisoxmes. Vesicle based trafficking: used by prtoeins that are secreted to extracellular space or inserted into plasma membrane, also used by proteins that are destined for the golgi or lysosomes. Vesicle based trafficking involves he following steps: proteins are synthesized in the rough er as described previously. Vesicle-based trafficking involves the following steps: proteins are then packaged into vesicles that fuse together to form the cis-golgi, from there, these proteins can return to the er or remain in the golgi as is matures. Golgi matures through retrograde transport of golgi enzymes and other proteins from older regions to newer regions. Additional post-translational modifications are made in the process. Proteins in mature trans-golgi network are then sent to final destination. Some proteins are synthesized as inactive proproteins that are cleaved in transit from trans-