MICR5814 Study Guide - Emulsion, Homothallism, Sinusitis
Document Summary
Mutational resistance: the bug becomes reistanct to the drug if mutation proves to be advantageous target site modification (e. g. lactam resistance change in pbp"s (penicillin binding proteins the penicillin binds to a specific site but mutation can occur resistant organism has a modified pbp), reduced permeability or uptake, metabolic by pass (e. g. trimethoprim resistance overproduction of dhf (dihydrofolate) reductase in s. aureus can degrade antibiotics), derepression of multidrug efflux systems. Drug inactivation (e. g. aminoglycoside modifying enzymes, lactamases, chloramphenicol, acetyltransferase), efflux system (e. g. tetracycline efflux), target site modification (e. g. methylation in the 23s component of the 50s ribosomal subunit erm methylases), metabolic by pass (e. g. trumethoprim resistance resistance to dhf reductase. The vegetative body may be unicellular (i. e. yeasts), composed of microscopic threads (hyphae) within internal divisions (septa) i. e. moulds), or many fungi have mass of hyphae (myceliu) hidden from view growing in a food source (e. g. rotting wood) only to be seen by its fruiting body (e. g. mushroom).
