300905 Study Guide - Final Guide: Hydrogen Sulfide, Lamina Propria, Gut Flora

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Document Summary

Many hypotheses have been raised for environmental factors contributing to the pathogenesis of ulcerative colitis. They include: diet: as the colon is exposed to many dietary substances which may encourage inflammation, dietary factors have been hypothesized to play a role in the pathogenesis of both ulcerative colitis and crohn"s disease. Few studies have investigated such an association; one study showed no association of refined sugar on the number of people affected of ulcerative colitis. High intake of unsaturated fat and vitamin b6 may enhance the risk of developing ulcerative colitis. Other identified dietary factors that may influence the development and/or relapse of the disease include meat protein and alcoholic beverages. Specifically, sulphur has been investigated as being involved in the cause of ulcerative colitis, but this is controversial. Sulphur restricted diets have been investigated in people with uc and animal models of the disease.