NUR5111 Study Guide - Final Guide: Anaphylaxis, Fluvastatin, Dobutamine
3 Mar 2021
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Chapter 10 drugs affecting noradrenergic transmission / chapter 21 drugs affecting vascular smooth muscle. 472-477; 480-484) cardiac glycosides; antidysrhythmic drugs / chapter 21 lipid-lowering drugs. Acts on all - and -adrenoceptor subtypes. Primacy action is on the -adrenoceptors of the heart, smooth muscle of the bronchi (bronchodilation) & blood vessels (vasodilation) Significant increase in myocardial contraction (positive inotropic effect) The dominant net response is often vasodilation. Causes renal artery constriction and increased resistance. Inhibits insulin secretion and decreases the uptake of glucose by peripheral tissue, raising. Stimulates lipolysis in adipose tissue, increasing free fatty acids in blood. Produces vasoconstriction at blood vessels of the skin, visceral organs & kidneys, causing reduce blood flow. Effecting changes in diastolic & systolic pressure, but peripheral vascular resistance coupled with compensatory vagal reflexes results in no change in hr and co. Large doses activates -receptors in the peripheral vascular system, resulting in an increase in peripheral resistance and in bp.
