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13 Dec 2019

Please show work: At which of the following pH values would histidine (pKa values of 1.8, 6.0, and 9.2) be found with a net negative charge?

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Jean Keeling
Jean KeelingLv2
17 Dec 2019

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Related questions

Histidine has ionizable groups with pKa values of 9.2, 6.0,and 1.8. A biochemist makes 100 mL of a 0.1 M solution of histidineat a pH of 5.4. She then adds 40 mL of 0.1 M HCl. What is the pH ofthe resulting solution?

Calculate % ionization for histidine imidazole ring at pH of7.0. Note that the following pKa values: 1.8, 6.0 and 9.3. Please fully show yourwork for full points.

80 mL of 0.05M histidine is adjusted to pH = 13.2. It is thentitrated with 0.1M
HCl to a final pH of 1.8. The pKa values of histidine are 1.8, 6.0and 9.1. Using
this information:

(a) Sketch the titration curve, labeling the pH and volume axes.Indicate clearly
the volumes of HCl needed to reach each pKa value, and to reach thepI of
histidine.

(b) Once the pH of the histidine solution reaches 1.8, it is thentitrated with 50 mL
of 0.1M NaOH. What is the final pH of the histidine solution?

Please be clear and have a good graph Thanks

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