1. A strain of mice has been developed that lack the enzyme phosphorylase kinase.
Despitethis, after strenuous exercise, glycogen is still broken down. Explain how
this is possible.
2. The complete oxidation of G6P derived from glucose yields 1 less ATP than G6P
derived from glycogen. Explain why.
3. Type 2 diabetes is a condition characterized by insulin resistance and high blood
glucose concentration. Research is underway to develop inhibitors of glycogen
phosphoryalse as a possible treatment. What is the rationale for this trategy and
what is one potential problem with this approach (consider the organs that have
phosphorylase)?
4. The active site of phosphorylase is hydrophobic so that water cannot get in.
What is the biochemical reason for wanting to exclude water from the active site?
1. A strain of mice has been developed that lack the enzyme phosphorylase kinase.
Despitethis, after strenuous exercise, glycogen is still broken down. Explain how
this is possible.
2. The complete oxidation of G6P derived from glucose yields 1 less ATP than G6P
derived from glycogen. Explain why.
3. Type 2 diabetes is a condition characterized by insulin resistance and high blood
glucose concentration. Research is underway to develop inhibitors of glycogen
phosphoryalse as a possible treatment. What is the rationale for this trategy and
what is one potential problem with this approach (consider the organs that have
phosphorylase)?
4. The active site of phosphorylase is hydrophobic so that water cannot get in.
What is the biochemical reason for wanting to exclude water from the active site?
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