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19 Nov 2019
Questions 5 and 7 are what I need help with! Thank you!
each of these washes and wRy Is ou anhydrous sodium sulfate. a. Why is this done? b. Could solid sodium hydroxide or potassium hydroxide be used for this 3. After the washes described in Exercise 2, the 1-bromobutane is treated w ith purpose? Explain. final step of the purification process in the Miniscale Procedure in volves a simple distillation. What impurities are removed by this distillation? 5. Using curved arrows to symbolize the flow of electrons, propose a mechanism for formation of the by-product(s) from elimination that could be produced when 1-butanol is treated with HBr. Specify whether your mechanism is E1, E2, or both. 6. List two factors, one in the substrate R-L and the other in the nucleophile /base Nu: being used, that should increase the yield of E2 relative to Sy2 products in the reaction of R-L with Nu: 7. Treating 1-butanol with sulfuric acid establishes an equilibrium with 1-butyl bisulfate and water as shown. 1-Butanol I-Butyl bisulfate Using curved arrows to symbolize the flow of electrons, propose a mecha- 1-Butyl bisulfate may serve as the precursor to an ether and an alkene, as i. Provide the structures expected for the ether and the alkene that might a. nism for the conversion of 1-butanol to 1-butyl bisulfate. b. well as the desired 1-bromobutane. be produced from 1-butyl bisulfate. i. Using curved arrows to symbolize the flow of electrons, provide reac tion mechanisms for the formation of each of these by-products and specify whether the mechanisms you write are SNl, SN2, E1, E2,or none of these. ii Explain why you would expect bisulfate to be a good leaving group for substitution or elimination reactions. 8. Consider the mechanistic step in the conversion of 1-butanol to 1-bromobu 14.10) e in which bromide ion displaces water from the oxonium ion 1 (Eq.1 What evidence, if any, is there that this step involves backside attack by a. the nucleophile?
Questions 5 and 7 are what I need help with! Thank you!
each of these washes and wRy Is ou anhydrous sodium sulfate. a. Why is this done? b. Could solid sodium hydroxide or potassium hydroxide be used for this 3. After the washes described in Exercise 2, the 1-bromobutane is treated w ith purpose? Explain. final step of the purification process in the Miniscale Procedure in volves a simple distillation. What impurities are removed by this distillation? 5. Using curved arrows to symbolize the flow of electrons, propose a mechanism for formation of the by-product(s) from elimination that could be produced when 1-butanol is treated with HBr. Specify whether your mechanism is E1, E2, or both. 6. List two factors, one in the substrate R-L and the other in the nucleophile /base Nu: being used, that should increase the yield of E2 relative to Sy2 products in the reaction of R-L with Nu: 7. Treating 1-butanol with sulfuric acid establishes an equilibrium with 1-butyl bisulfate and water as shown. 1-Butanol I-Butyl bisulfate Using curved arrows to symbolize the flow of electrons, propose a mecha- 1-Butyl bisulfate may serve as the precursor to an ether and an alkene, as i. Provide the structures expected for the ether and the alkene that might a. nism for the conversion of 1-butanol to 1-butyl bisulfate. b. well as the desired 1-bromobutane. be produced from 1-butyl bisulfate. i. Using curved arrows to symbolize the flow of electrons, provide reac tion mechanisms for the formation of each of these by-products and specify whether the mechanisms you write are SNl, SN2, E1, E2,or none of these. ii Explain why you would expect bisulfate to be a good leaving group for substitution or elimination reactions. 8. Consider the mechanistic step in the conversion of 1-butanol to 1-bromobu 14.10) e in which bromide ion displaces water from the oxonium ion 1 (Eq.1 What evidence, if any, is there that this step involves backside attack by a. the nucleophile?
Irving HeathcoteLv2
25 Jun 2019