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11 Nov 2019
(12 pts) L-Tyrosine is an amino acid necessary for the biosynthesis of L-thyroxine (also known as T4). The structures of tyrosine and thyroxine are shown below. What is the configuration of the chiral carbon in the L-isomer (R or S) of L-tyrosine? Use perspective formulation to indicate the stereochemistry on the structures provided. a. COH NH2 Tyrosine Thyroxine L-Tyrosine has three pKa values, 2.2, 9.1 for the conjugate acid of the amine, and 10.1 for the phenol. At what pH does tyrosine T4 have no net charge? b. The pKa values listed for L-thyroxine are 2.2 and 6.7 for the acidic groups, and 10.1 for the conjugate acid of the amine. Draw the MAJOR form of the drug that exists at physiological pH (7.4). c. d. At what pH does T. have no net charge?
(12 pts) L-Tyrosine is an amino acid necessary for the biosynthesis of L-thyroxine (also known as T4). The structures of tyrosine and thyroxine are shown below. What is the configuration of the chiral carbon in the L-isomer (R or S) of L-tyrosine? Use perspective formulation to indicate the stereochemistry on the structures provided. a. COH NH2 Tyrosine Thyroxine L-Tyrosine has three pKa values, 2.2, 9.1 for the conjugate acid of the amine, and 10.1 for the phenol. At what pH does tyrosine T4 have no net charge? b. The pKa values listed for L-thyroxine are 2.2 and 6.7 for the acidic groups, and 10.1 for the conjugate acid of the amine. Draw the MAJOR form of the drug that exists at physiological pH (7.4). c. d. At what pH does T. have no net charge?
Irving HeathcoteLv2
26 Jan 2019