KINESIOL 2Y03 Lecture Notes - Lecture 3: Zona Pellucida, Zp3, Pronucleus

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1st sperm binds to integrin 26ft on oocyte plasma membrane (cid:8869) causes depolarization - electrical change of oocyte plasma membrane. Shocks all other sperm (fast block to polyspermy ) slow block to poly spermy. Oocyte shrinks - zona pellucida denatures (cid:8869) causes space. Female nucleus undergoes 2nd meiotic division (cid:8869) ovum 1- 2nd polar body. Sperm head turns into the male pronucleus. Haploid pronucli fuse and form single nucleus (cid:8869) zygote (diploid. ) usually. ~ 6- 36hrs to occur iz or more. Morula breaks free from zona pellucida (hatching) (cid:8869) secretes fluid - pushes cells to side + creates cavity filled w/ fluid. Cells survive of cells cytosol nutrients + uterine milk (glycogen rich) { entered uterine cavity - will undergo implantation. Totipotent : can become any cell type in the body cells become pluripotent (cid:8869) started to differentiate (cid:8869) can"t form all types anymore detected in urine (pregnancy tests) release hormone : human chorionic.

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