BIO Lecture Notes - Lecture 1: Hans Adolf Krebs, Citric Acid Cycle, Acetyl-Coa
2 Nov 2022
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The complete cycle was proposed by sir hans krebs in 1937. The cycle is therefore named after him. Please note that the name is krebs cycle (there is no apostrophe) Preparatory steps : acetyl coa enters the cycle, and is completely oxidized, during this process, energy is trapped. Pyruvate derived from glycolysis is oxidatively decarboxylated to acetyl coa by the pyruvate dehydrogenase. This is the link between the tca cycle and glycolysis. All the enzymes of citric acid cycle are located inside the mitochondria. 1st step: formation of citric acid, oxaloacetate (4 carbon) is condensed with acetyl coa (2 carbon) to form citrate (6 carbon). 2nd step: formation of isocitrate, citrate is isomerized to isocitrate by aconitase . At first, one water molecule is removed from citrate forming cis aconitate; a transient compound. Immediately, one water molecule is added to aconitate to form isocitrate.
