BIO Lecture Notes - Basophil, Bradykinin, Anaphylaxis
2 Nov 2022
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Diameter of a basophil is similar to neutrophil and eosinophil, i. e. 10 14. Nucleus of basophils is irregular, may be bilobed or trilobed, and its boundary is not clearly defined because of overcrowding with the coarse granules. Cytoplasm of basophils is slightly basophilic and appears blue. Granules of basophils are very coarse and stain deep purple or blue with basic (methylene) dye. Granules are in plenty and completely fill the cell and overload the nucleus. The granules of basophils contain heparin, histamine and 5-ht. Basophils also release eosinophil chemotactic factor that causes eosinophils to migrate towards the inflamed allergic tissue. Eosinophils then phagocytose and destroy antigen antibody complexes and prevent spread of local inflammatory process: release of heparin. Prevents clotting of the blood and activates the enzyme lipoprotein lipase, which removes fat particles from the blood after a fatty meal. Basophilia refers to increase in the basophil count (absolute count > Viral infections, e. g. influenza, small pox and chicken pox,
