Lecture : HAEMOGLOBIN-FUNCTIONS-SYNTHESIS-STRUCTURE-DERIVATIVES-HEMOGLOBINOPATHIES
2 Nov 2022
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The cytoplasm of erythrocytes (rbcs) contains an oxygen binding protein called haemoglobin. While the mature erythrocytes lose the property of synthesizing haemoglobin. Functions of haemoglobin: transport of o2 from lungs to tissues. In the lungs, one molecule of o2 is attached loosely and reversibly at the sixth covalent bond of each iron atom of the hb to form oxyhaemoglobin represented as hbo2. The affinity of hb for oxygen is influenced by ph, temperature and concentration of 2,3-diphosphoglycerate, i. e. 2,3-dpg (a product of metabolism of glucose) in the rbcs: transport of co2 from the tissues to the lungs. Hb also transports co2 from the tissues to the lungs. Co2 from the tissues is transported by combining with amino acids of the globin part as shown below and not in combination with fe2+ atom like o2. Deoxygenated hb forms carbamino-hb more readily than oxygenated hb.
