MEDICAL TECHNOLOGY Lecture 1: Clinical Chemistry 2

• School: Lyceum of the Philippines University
• Department: Health Sciences
• Course: MEDICAL TECHNOLOGY

Document Summary

Thyroid gland: follicular cells secrete t3 & t4 (major thyroid hormones, parafollicular cells (c cells) secrete calcitonin (for calcium metabolism) Transport protein: thyroxine-binding globulin (tbg) 70-75% of total t4, thyroxine-binding prealbumin 15-20% of total t4, albumin 10% of total t4, most-t3. Weight loss (increase utilization of bmr) loss of muscle mass (due to increase metabolic activity) insomnia increased sweating nervousness. Immunological disorder in which immunoglobulins bind to tsh receptors in the thyroid cell and stimulate the production & release of thyroid hormones. Goiter, hyperthyroidism, ophthalmopathy (bulging eyes) & occasionally pretibial edema. Usually occurs in patients with pre-existing nodular goiters. Portions of the thyroid gland are no longer under normal feedback control & secrete excess amounts of thyroid hormone. Not accompanied by ophthalmopathy nor pretibial edema. Benign tumors that do not respond to normal control mechanisms and can occasionally produce excess thyroid hormone. Presence of thyroid nodules that concentrate radioactive iodine. Inflammation of the thyroid gland, causing hypersecretion of thyroid hormones.