KINESIOL 2Y03 Lecture Notes - Lecture 3: Protein Folding, Complex Differential Form, Chloroplast
26 Sep 2021
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Module 2: protein structure and function; lecture 1: The objectives of this lecture are to identify the principles for helping proteins to fold; to describe the mechanisms employed by molecular chaperones and chaperonin complexes; and to describe the two step process required for protein degradation. One option is to assist protein folding using the machinery within the cell. Mechanisms that assist protein folding employ the same general principle to prevent inappropriate interaction. Molecular chaperones and chaperonin complexes approach this task in slightly different ways. If the protein ultimately cannot be folded, aggregates can form which can be detrimental to the cell. Instead, the cell removes these proteins via degradation in the proteasome. Slide 4 chaperones fall into 2 classes: the first class includes monomeric molecular chaperones and the second class includes the multimeric chaperonin complex. Both of these assist protein folding in essentially the same way.
