E62 BME 140 Lecture Notes - Lecture 1: Biomaterial, Extracellular Fluid, Tissue Engineering
8 Sep 2015
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Intensive properties: not dependent upon size (density, mole fraction, temperature) Extensive properties: dependent upon size and sample selected(mass, volume, energy) basic differential equation governing current through a patch of neuronal cell membrane ionic current: delta_v = v - v_l. C_m * dv/dt = -(v - v_l) / r_m. Sakiyama-elbert lecture: biomaterials for drug delivery and tissue engineering. Tissue engineering is an interdisciplinary field that applies the principles of engineering and the life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function. 3 main parts: cells, matrix (extracellular matrix), tissue equivalent. Extracellular matrix: holds cells together to aid tissue formation. Normal tissue: multicellular, 3 dimensional structure, extracellular matrix, multi-functional, takes cues from the environment (produce insulin if high glucose), interfaces with surroundings. Must consider all aspects to successfully engineer tissue. Bone, skin, pancreas, heart valves, arteries, and veins, saliva glands, urinary tract, bladder, cartilage, teeth, breast, liver, spinal cord nerves.
