PSY 3100 Lecture Notes - Lecture 15: Antipsychotic

• School: Vanderbilt University
• Department: Psychology (A&S)
• Course: PSY 3100
• Professor: Olatunji Olubunmi(bunmi)

Document Summary

Many americans take antidepressant medications = 11 % total. Drug treatments for mood disorders: newer generation antidepressants (e. g. ssris) The case of prozac: 3 trials showed a statistically significant advantage of prozac vs. placebo; 2 did not, averages across all trials: Average improvement with prozac = 8. 3 points on ham-d. Average improvement with placebo = 7. 34 on ham-d: 89% of drug effect duplicated with placebo. The fda approved prozac for adults in 1987. Marketing prozac trial in scientific journals: actual vs. Apparent efficacy: published studies ignore the trials that didn"t work, the results are more intense. This despite biased trial design: drug was significantly more effective than placebo in 94% of published trials. Felling not like myself: caring less about others, reduction in positive feelings, sexual difficulties, suicidality***, withdrawal effects. Antidepressant"s black box warning - people must balance the risk of increased suicidality with the clinical need: results: people just stopped prescribing them.