BIOL 4170 Lecture Notes - Lecture 1: Transforming Growth Factor Beta, Insulin Receptor, Transmembrane Protein
16 Jun 2016
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Paracrine smaller groups of cells nearer to each other. Good for tissue organization stuff, underlies a lot of cancers and bad things. Synaptic presynaptic needs to be on postsynaptic terminal, ligand has to be small, low kd, short half life, high concentration, neural communication needs to be fast. Little difference in concept between this and paracrine but nature of half life and affinities are different. Synaptic have to be right up next to their target. Contact dependent (cells interacting with each other this way, actually touching) Communicate through cellular channels (let ions pass between them, important for muscle contraction) Gap junctions: let slightly bigger molecules pass through. Juxtacrine signaling (touching, but talking through ligand receptor interaction which occurs through a tethering on the membrane) Between cell and extracellular matrix (doesn"t have to be between 2 cells) think about the differences between upper and lower intestinal epithelial. First signaling messengers (these range in size)
