BIOL 2100 Lecture Notes - Lecture 31: Tumor Suppressor Gene, P53, E2F
10 Oct 2016
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Document Summary
Dna damage checkpoint occurs all throughout the cell cycle. Checkpoint can act either independently or in association with cdks. Cells are continuously making the protein p53, while also constantly destroying it. When dna is damaged, p53 changes structure and becomes phosphorylated. This means the cell no longer is able to destroy it. It does not recognize it as p53 anymore. In doing so, pauses the cell cycle. Can activate the enzyme to fix dna damage. Inhibits the inhibitor that stops cell death. Cdks are regulated through cyclin and their phosphorylation state. Wants cells to grow so virus can replicate and spread. Cdk puts a phosphate group on rb. Hpv has genes that encodes proteins that bind to rb that leads to a release of e2f. Cell then releases a protein that inhibits the inhibitor that stops p53 (releases p53) Meiosis is present in all sexually reproducing organisms. The purpose is to create genetic diversity.
