BIOL 3600 Lecture Notes - Lecture 22: Hmg-Coa Reductase, Phosphatidic Acid, Endoplasmic Reticulum
25 Apr 2020
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Main ideas: glycerol and fatty acids make phosphatidate, the precursor to tag"s and phospholipids, acetyl-coa is made into hmg-coa then into mevalonate then activated isoprene (ipp). #2 glycerol and fatty acids make (a compound you need to remember for sure) phosphatidate, the precursor to tag"s and phospholipids. Glycerol-3-phosphate is available to us, so it provides the glycerol background and 2 fatty-acids are added. Can put a number of fatty-acids on those locations. Glycerol comes from hydrolysis of fats and also from dhap in the glycolytic pathway. Can make phosphatidate in the endoplasmic reticulum, liver the highlighted organ/cells. Can add an amino alcohol and make phospholipids that we"ve seen earlier in the semester. We can add another fatty-acid and make triacylglycerides. #5 acetyl-coa is made into hmg-coa then into mevalonate (mevalonic acid) then activated isoprene (ipp). All lipids are biosynthesized from acetyl-coa (starting material for isoprenoids and lipids). Mevalonic acid, mevalonate is the carbonate that dominates the ph.
