NEU 365D Lecture Notes - Lecture 22: Lung Cancer, Intron, Growth Factor
Document Summary
Chances of developing some sort of cancer in your lifetime: 1 in 3. Longer you live - more likely you are to get it. Due to mutations in key genes involved in cell growth, division, suppression of cell division, etc. One mistake leads to another to another: cascade of errors. Prevalence - percentage of patients in a population that have a disorder/disease. Incidence - how many cases you get in a year (~2 million per year in us) Estimated new cancer cases in the us per year. Can get breast cancer, just not as likely. Increased odds for mistakes to be made and something not to be caught and fixed by mechanisms. Most cancers primarily due to environmental factors (60-90%) Nongenetic factors: diet, environmental chemical exposure, cultural and behavioral practices. Ex: constant exposure to cosmic rays, metabolism of food (make reactive agents) normally fixed/dealt with. Lot of mutations are innocuous: i. e. in an intron (cut out anyways)
