NEU 365D Lecture Notes - Lecture 14: Myasthenia Gravis, Gaba Receptor, Ondansetron
Document Summary
10/02 - lecture 14: lgics (ligand-gated ion channels) Aps travel down the axon (wave of depolarization mediated by na + channels) lead to. Nt release by opening voltage-gated ca 2+ channels at the presynaptic terminal. Neurotransmitters (nts) - small molecules released by neurons that bind to receptors an elicit functional effects. Ondansetron - antagonist of 5-ht 3 (only lgic of 5-ht receptors) Ketamine - antidepressant acts faster than typical depression medicines. Increases likelihood of postsynaptic cells to generate an ap. Increases membrane potential makes it more positive) Postsynaptic cell response to nt dependent on: The magnitude of the response dependent on : Disease state ex: myasthenia gravis decreased number. Receptors become desensitized after a period of time when the nt is still present. Cycling between closed and opened states population in present of [nt] Desensitized receptor is no longer able to respond to nt. Caused with repeated activation of a synapse increases likelihood of some of the receptors to desensitize.
