NEU 365D Lecture Notes - Lecture 4: Evans Blue, Body Water, Time Point
Document Summary
Drug distribution volume distribution: after the drugs get into the body - concentration over time. Extrapolate back to time point zero when nothing mg/ mg/l l units has been excreted yet. Can only measure concentration at different points in time after a certain amount of time has passed. Even after injecting intravenously - takes time to distribute to their sites of action. Some drugs (i. e. alcohol) goes into total body water. Don"t have access to the same bodies of water. Some water is easily accessible - interstitial fluid, blood, etc. Other locations (i. e. water in ligaments) harder to access poor circulation is the reason it takes so long to heal. Sugars - only found extracellularly - can"t pass cell membrane. Ex: mannitol (sugar) - not transformed in the body (excreted unchanged by kidneys) Concentration goes down over time as the kidney removes it from the body. Measure in blood stream over time extrapolate the line back to time zero.
