BME 410 Lecture Notes - Lecture 12: Chondroitin Sulfate, Lysine, Type I Collagen
20 Apr 2016
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Document Summary
Post translational modifications: control protein function and diversity through enzymatic chemistry. Matrix metalloproteinase (mmp) can cleave components of the extracellular matrix resulting in increased space for cell or tissue movement. Fill interstitial space and act as compression buffer against the stress placed on the. >25 different collagen genes (col1a1, col2a1, col4a6, etc) with slightly (cid:2) (cid:2) (cid:2) (cid:2) (cid:2) (cid:2) (cid:2) (cid:2) different amino acid sequences. Select prolines and lysines are hydroxylated (addition of an oh: vitamin c is essential co-factor, scurvy. Characterized by weakness, anemia, bruising, bleeding gums, loose teeth. Different alpha-chains (from the >25 different collagen genes) assemble to form different collagen types. Differences in: alpha-chain sequence, propeptide structure and cleavage (cid:2) Skin, muscle, blood vessels (often associated with type i) Collagen type xi: n-propeptide completely removed, tight, dense, thick fibrils, n-propeptide not completely removed, steric hindrance, thin fibrils core microfibrils.
