BPS 432 Lecture Notes - Lecture 40: Dopamine Beta-Hydroxylase, Tricyclic Antidepressant, Monoamine Oxidase
6 Feb 2017
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*abnormal blood flow and brain activity affective. Ventral tegmental area (vta midbrain) cortical, limbic, nucleus accumbens. Arise in locus ceruleus in bs all areas. Excitatory, arousal, activation innervate entire cerebral cortex. Serotonin raphe nuclei (bs) all areas repletion, satistfaction. Depression rise in temperature occurs several hours later. No sleep - tx not effective or sign of relapse. Anti depressant site catecholamines = dopamine, ne - from tyrosine indoleamines = serotonin - from tryptophan. Catecholamine nt synthesis tyrosine dopa dopamine ne. Enzymes : tyrosine hydroxylase dopa decarboxylase dopamine - beta- hydroxylase. L - tryptophan 5htp 5ht. Mechanisms a1 - gq, plc, ca, ip3 ^ a2 - gi, ac, camp, ca dec. ; k ^ Termination of monoamine signals release nt presynaptic nerve (reuptake) Once nt back in nerve, oxidized into inactive form by family of enzymes (mao) Nt not inactivated repackaged via vmat catecholamines decgraded by comt in post-synapse. But a also found in liver, gi tract.
