BIOL 522 Lecture Notes - Lecture 3: Human Accelerated Regions, H3K27Ac, Conservation-Dependent Species
Document Summary
Chimps are our closest relative in terms of protein coding sequences (conserved between humans and chimps) Foxp2 is in speech and development - phylogeny to look at amino acid mutations. Sequenced chimp genome in 2005 - low human chimp divergence in genome sequence. Human accelerated regions (har) - changes just in human dna seq. Nchar (non coding har) more likely in the regulatory regions. Fig 1 = different methods give different yields. =not just reliant on conservation, some are semi-conserved. Epigenetics = changes to an organism that isn"t encoded in dna, everything else is under the umbrella term of epigenetics, focuses on nucleosome (core histone proteins) Epigenetics focuses on histone tails" interaction with dna. Tails can be modified with methylation, acetylation, phosphorylation. Dna methylation of base pairs for regulatory control in epigenetics - none of the actual dna seq changes but position of nucleosomes and marks (eg. dna methylation) changes. Overlap in har but they may not overlap in function.
