BIOL 483 Lecture Notes - Lecture 37: Prc2, Cenpa, Embryonic Stem Cell
Document Summary
Easy to remember because there"s the addition of the large macro domain (like another third of a histone) so it"s very often repressive. H3. 3 and cenpa are replication independent, not doing s phase. Very similar to h3. 1, 96% homology (cenpa has 45% homology) H3. 3 is like h2a. z because it can be repressive and active. Repressive at bivalent promoters in embryonic stem cells, marked by h3. 3k27me3. Linked to gene activation during differentiation - more commonly studied. Often linked with activating mark h3. 3k36me3 at active genes. Crosstalk that we haven"t talked about is h3. 3k36me3 is in complete opposition with h3. 3. Transcriptional memory of active genes due to differentiation. Related to unique readers of histone variants as well as some ptms that are associated. Transcriptional memory = when duplicating genes, we need to remember what has been active, it"s like a housekeeping genes, essential gene for survival, must remember that"s an active gene that must always be on.
