PCD 8117 Lecture Notes - Lecture 19: Dental Fluorosis, Steven Levy, Fluoride
3 Jan 2020
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Document Summary
An understanding of fluoride metabolism and toxicology is important for the. Significance: proper and safe use of fluoride for caries prevention. Distribution throughout body-~95% found in skeleton: bone can release f slowly, so it is a reservoir. Pharmacokinetics of fluoride-rates: when f is complexed with something or as a solid, then abs rate is slower, as liquid, faster abs. Uptake in teeth and bone and teeth(pre-eruptive maturation: no accumulation in the thyroid and rapid clearance in the kidneys. Historical findings: signs of f overdose = nausea, vomiting, diarrhea, cramping then collapse, coma, death (2-4 hrs, treat with milk of magnesia or aloh. Skeletal fluorosis vs. tooth fluorosis: skeletal bone fractures, curvatures, tooth striations, not a real problem unless very severe. Acute toxic dose(lethal)- 35-70 mg f/kg body weight. Concentration of fluoride rule of thumb-how to calculate ingestion: rule of thumb, naf = concentration, snf2 = concentration, mfp = 1/8 concentration.
