LIFE 120 Lecture Notes - Lecture 19: Trp Operon, Missense Mutation, Essential Amino Acid
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Thursday december 15th 10am-12pm, beadle e103 (same lecture hall) A: it might substitute a different amino acid in the active site. Sickle-cell disease is caused by a missense mutation. 1 bp change in dna produces single aa change in protein. Q: if a particular operon encodes enzymes for making an essential amino acid and is regulated like the trp operon then, A: the amino acid acts as a corepressor. A: bind to other proteins or to a sequence element within the promoter called the tata box. Control elements are segments of noncoding dna that serves as binding sites for transcription factors (tfs) that help regulate transcription. Proximal elements: upstream but close to a specific gene promoter. Enhancer elements: distal or distant from promoter but regulate only that specific gene. Q: proto=oncogenes can change into oncogene that cause cancer. A: they can give rise to all cell types and organisms.
