SOC 1001 Lecture Notes - Lecture 11: Lac Operon, Lac Repressor, Trp Operon
Document Summary
Gene regulation means the level of gene expression can vary under different conditions. Constitutive genes: genes that have a constant level of expression, unregulated genes. Transcriptional regulation involves the actions of regulatory proteins that bind to the dna and affect the rate of transcription. Repressors inhibit transcription, which is called negative control. Activators increase transcription, which is called positive control. The actions of the repressors or activators are modulated by effector molecules. Inducers are effector molecules that cause an increase in transcription. Genes that are regulated in this manner by inducers are called inducible. Corepressors are effector molecules that bind to repressors, causing the repressor to bind to the dna. Inhibitors bind to an activator protein and prevent it from binding to the. Genes that are regulated in this manner are called repressible. Current understanding of gene regulation can be traced back to jacob and. They examined lactose metabolism in e. coli (the lac operon)
