PSY 3061 Lecture 8: Biopsychology lecture 2.21.2018
Document Summary
Gives enormous temporal precision as well as facial precision. Opsins: prototypical g protein-coupled receptors (gpcrs) that require a cofactor, retinal, to absorb photons, found in many animals (usually in different cells, found in the eye, transported ions, channelrhodopsin, halorhodopsin, bacteriorhodopsin, signaling pathways, vertebrate rhodopsin fused to conv. Gpcrs: channels are not active unless specific frequency of light is shined on cell. In control as for when and how long these cells are activated or inhibited: there are secondary intercellular effects of inhibition and excitation. Recombinase: enzyme protein: only cells containing recombinase will express the channel. Very precise method via viral transection that causes the expression of light-sensitive channels in specifically targeted cells or channels. Benefits and limitations: pros, cellular and projection specificity, high temporal precision, reversible, cons, stimulation not physiological, access to the structure of interest. Lower order sensation to higher order perception: receptors, thalamic relay nuclei, primary sensory cortex, secondary sensory cortex, association cortex.
